Endocrine Abstracts

Kisspeptin and neurokinin B are 2 novel key hypothalamic hormones which are vital in normal reproductive function. Inactivating mutations for the gene or the receptor for either of these peptides will cause a failure of puberty due to hypogonadtotrophic hypogondaism. In this talk I will present evidence to suggest that kisspeptin is important in sexual and emotional processing in humans (1). In addition I will present evidence which suggests that NK3R (the receptor for NKB in ...

Background: More than 1.9 billion people in the world are suffering from overweight. Damages can be caused to the liver such as fatty liver or even Cirrhosis. The aims of this study are to determine the prevalence and the impact of steatosis and overweight on therapeutic response in chronic hepatitis B.Methods: This is a descriptive transversal study enrolled from 01/2010 to 09/2018. All patients with chronic hepatitis B investigated by liver biopsy were...

We present a rare case of Non- Hodgkins large B Cell lymphoma presenting as circulatory collapse and acute adrenal insufficiency. A 47 year old woman was referred with a 1 month history of weight loss of 7 kg and vomiting. Shortly after admission her condition deteriorated and she developed acute hypotension, BP was 92/58 mmHg, heart rate 100/mn and required volume resuscitation. Examination revealed a thin woman with generalised hyperpigmentation. Serum sodium was 130 mmol/l,...

Introduction: Thyroid lymphoma is a rare disease. Furthermore, coincidence of extrathyroidal lymphoma is very rare.Case: A 69 years-old woman patient was admitted to the hospital with dyspnea, hoarse voice and swelling of throat for a month. In her history, she had been diagnosed as gastric lymphoma 6 years ago, while she was being investigated for upper gastrointestinal bleeding. Six cures of chemotherapy has been applied. She was not on follow up. In p...

Malignant glucagonomas are slow-growing tumours which more commonly cause symptoms through glucagon hypersecretion than through effects of tumour bulk. The glucagonoma syndrome includes necrolytic migratory erythema (NME), diabetes mellitus, weight loss, anaemia, chelitis, venous thrombosis and neuropsychiatric symptoms. The syndrome probably results from unrestrained proteolysis1, and rapid consumption of B-vitamins through accelerated intermediate metabolism2...

Puberty is a tightly regulated process through which an individual attains reproductive capability. An intricate network of central and peripheral factors play a role in this process; however, the cellular and molecular events that initiate and sustain adult reproductive function remain largely unknown. Recently, kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have been shown to be gate-keepers of puberty...

Case history: A 56 year old man presented with a few months history of diffuse bone pain affecting his arms, legs, ribs and particularly his left hip. Past medical history included well controlled HIV infection, hepatitis B co-infection, peripheral neuropathy associated with HAART, lipoatrophy, Kaposi’s sarcoma, ADHD, type 2 diabetes mellitus, and a history of previous Fanconi’s syndrome associated with Tenofovir Disoproxil Fumarate (TDF) 8 years ago. At his initial ...

Background: The hypothalamic neuropeptides kisspeptin and neurokinin B (NKB) are both obligate for normal gonadotrophin secretion. Studies in patients with loss-of-function mutations in NKB signalling suggest that kisspeptin is functionally upstream of NKB, but this hierarchy is unexplored in healthy men and women. We hypothesised that kisspeptin augmentation of estrogen-induced mid-cycle LH secretion will not be abrogated by pharmacological blockade of NKB.<p class="abste...

IntroductionPrimary thyroid lymphoma (PTL) is a rare affection that represents only 1% to 5% of thyroid malignancies and 1% to 2% of extranodal lymphomas. It involves by definition only the thyroid gland and adjacent neck lymph nodes, at diagnosis.Case presentation:A 65-year-old woman with a controlled Hashimoto’s thyroiditis presented with a 12-month history of painless neck swelling, recently increasin...

Central obesity is strongly associated with sub-clinical inflammation, insulin resistance (IR) and type 2 diabetes mellitus (T2DM), but the intracellular mechanisms involved in the pathogenesis of central obesity remain unclear. Recent studies have implicated NFκB and c-jun N terminal kinase (JNK) as central molecules linking insulin action and inflammation in mice. As such we examined (1) the inflammatory intracellular signaling pathways involving NFκB, JNK as a pot...